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Effect soflow-molecular-weight citrus pectin on the sensitivity of colon cancer cell lines to oxaliplatin WANGFeng£¬LIUHai-ying£®Department of Gastrointestinal Surgery£¬the Affiliated Tumor Hospital of Guangzhou Medical College£¬Guangzhou510095£¬China
¡¾Abstract¡¿ Objective To compare the effect of oxaliplatin solo and the combination of oxaliplatin and lowmolecular-weight citrus pectin £¨LCP£© on the proliferation of colon carcinoma cell lines in vitro£¬ and investigate whether LCP would influence the sensitivity of these cells to oxaliplatin£® Methods Human colon carcinoma cell lines HT29£¬ HCT116£¬ SW116£¬ SW480 were subjected to oxaliplatin or oxaliplatin plus LCP in various
concentrations for 72 h£¬ and the sensitivity of these cells to oxaliplatin was tested by cell morphology observation and activity testing by MTT£® Results There was suppressing effects of different concentrations of oxaliplatin on human colon carcinoma cell lines HT29£¬ HCT116£¬ SW116£¬ SW480£® LCP could strengthen the inhibiting effect of oxaliplatin on human colon carcinoma cell lines£® Conclusion LCP could increase the sensitivity of human colon carcinoma cell lines to oxaliplatin.
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1.HsuDK£¬YangRY£¬LiuFT£®Galectins in apoptosis £ÛJ£Ý£®Methods Enzymol£¬2006£¬417£º256£273£®
2.OishiT£¬ItamochiH£¬KigawaJ£¬etal£®Galectin-3 may contribute to Cisplatin resistance inclear cell carcinoma of the ovary£ÛJ£Ý£®IntJGynecolCancer£¬2007£¬17£¨5£©£º1040£1046£®
3.WongkhamS£¬JunkingM£¬WongkhamCH£¬etal£®Suppression of galectin-3 expression enhances apoptosis and chemosensitivity in liver fluke-associated cholangiocarcinoma£ÛJ£Ý£®CancerSci£¬2009£¬100£¨11£©£º2077£2084£®
4.Nangia-MakkerP£¬BalanV£¬RazA£®Regulation of tumor progression by extracellular galectin-3£ÛJ£Ý£®Cancer Microenviron£¬2008£¬1£¨1£©£º43£51£®
5.LiuHY£¬HuangZL£¬YangGH£¬etal£®Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model£ÛJ£Ý£®WorldJGastroenterol£¬2008£¬14£¨48£©£º7386£7391£®
6.ChauhanD£¬LiG£¬PodarK£¬etal£®A novel carbohydrate-based the rapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis inmultiple myeloma cells£ÛJ£Ý£®CancerRes£¬2005£¬65£¨18£©£º8350£8358£®
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