918搏天堂

接待会见918搏天堂官方网站!

文献资料

联系918搏天堂

918搏天堂

电话:0570-8788056

传真:0570-8788381

邮箱:zjgykp@163.com

地点:浙江省衢州市东港经济开发区

东港4路2号

您所在的目今位置:首页 > 文献资料 > 肿瘤类文献
  • Galectin-3抑制神经性疼痛周围神经损伤后衰减
  • 宣布时间: 2019/4/15 点击次数:3439 
  •  

    Galectin-3抑制与神经性疼痛周围神经损伤后衰减
    Zhicong Ma1,2☯, Qi Han3☯, Xiaolei Wang3☯, Zisheng Ai4, Yongjun Zheng3* 

     
      摘要
      神经性疼痛仍然是一个普遍和长期的临床问题,因为它通常是不适应目今使用止痛剂 。很是迫切需要开发出新的药物来缓解神经性疼痛 。Galectin-3 (gal3)是一种多功效卵白属于汽车——bohydrate-ligand凝集素家族,由差别的细胞表达 。新兴的研究标明gal3诱导出促炎症反应通过招募和激活lympho cytes,巨噬细胞和小胶质细胞 。在这项研究中,我们视察是否gal3抑制会抑制周围神经损伤后神经炎症缓和解神经性疼痛 。我们发明L5脊神经结扎(SNL)增加的表达在背根神经节gal3 mRNA和卵白水平 。鞘内治理修改柑橘果胶(MCP), gal3抑制剂,减少gal3表达式在背根神经节 。

    Galectin-3 Inhibition Is Associated with Neuropathic Pain Attenuation after Peripheral Nerve Injury
    Zhicong Ma1,2☯, Qi Han3☯, Xiaolei Wang3☯, Zisheng Ai4, Yongjun Zheng3*
    1 Department of Anesthesiology, The 2nd Hospital of Shanxi Medical University, Taiyuan, 030001, China,
    2 Department of Anesthesiology, Xiangya Hospitalaffiliated to Central South University, Changsha 410008, China, 3 Department of Pain Management and Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital affiliated to Fudan University, No.221, West Yan'an Road, Shanghai, 200040, China,
    4 Department of Preventive Medicine, College of Medicine, Tongji University, Shanghai 200092, China
    ☯ These authors contributed equally to this work.
    *
    zhengyongjun1971@126.


    Abstract
    Neuropathic pain remains a prevalent and persistent clinical problem because it is often poorly responsive to the currently used analgesics. It is very urgent to develop novel drugs to alleviate neuropathic pain. Galectin-3 (gal3) is a multifunctional protein belonging to the car- bohydrate-ligand lectin family, which is expressed by different cells. Emerging studies showed that gal3 elicits a pro-inflammatory response by recruiting and activating lympho- cytes, macrophages and microglia. In the study we investigated whether gal3 inhibition could suppress neuroinflammation and alleviate neuropathic pain following peripheral nerve injury. We found that L5 spinal nerve ligation (SNL) increases the expression of gal3 in dorsal root ganglions at the mRNA and protein level. Intrathecal administration of modified citrus pectin(MCP), a gal3 inhibitor, reduces gal3 expression in dorsal root ganglions. MCP treatment also inhibits SNL-induced gal3 expression in primary rat microglia. SNL results in an increased activation of autophagy that contributes to microglial activation and subsequent inflammatory response. Intrathecal administration of MCP significantly suppresses SNL-induced autop- hagy activation. MCP also inhibits lipopolysaccharide (LPS)-induced autophagy in cultured microglia in vitro. MCP further decreases LPS-induced expression of proinflammatory media- tors including IL-1β, TNF-α and IL-6 by regulating autophagy. Intrathecal administration of MCP results in adecreased mechanical and cold hypersensitivity following SNL. These results demonstrated that gal3 inhibition is associated with the suppression of SNL-induced inflammatory process andneurophathic pain attenuation.

  • 上一篇:果胶与癌症治疗综述
    下一篇:果胶诱导人前列腺癌细胞凋亡:果胶结构与诱导细胞凋亡功效的相关
  • 返回新闻列表
 

    联系918搏天堂

  • 地点:浙江省衢州市东港经济开发区东港4路2号
  • 联系电话:0570-8788056
  • 咨询热线:400-7118-600
  • E-mail:zjgykp@163.com

Coptyright © 2018 zjgykp.com All Rights Reserved. 版权所有 918搏天堂   技术支持:浙江芝麻开门  浙ICP备19048970号-1|后台治理
网站地图
友情链接:米乐M6官网  来利国际w66  金年会  美狮贵宾会  9游会官网  必威betway  人生就是博-尊龙凯时  ag亚娱官网  yy易游  永乐F66  金年会  pg电子  凯发k8官网  米乐M6  pg电子