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  • 高温度-和处理ph值-改性柑橘果胶抗肿瘤作用比较研究
  • 宣布时间: 2019/3/13 点击次数:2515 
  • 高温度-和处理ph值-改性柑橘果胶抗肿瘤作用比较研究

     《食品&功效》 ,2013 ,4 ,960-971

    摘要

    通过高温和PH处理柑橘果胶获得低分子量改性果胶 。本实验比较了高温改性果胶(HTCP)和PH改性果胶(MCP)关于8种肿瘤细胞以及S-180肿瘤模型小鼠的效果 。实验结果标明 ,HTCP能抑制肿瘤细胞增生 ,诱导caspase-3依赖性的细胞凋亡和G2/M阶段的细胞周期停滞 ,延长肿瘤小鼠的生存时间 ,其肿瘤只有比照组的49% 。MCP则关于肿瘤细胞和癌症小鼠效果不明显 。实验结果同时标明 ,HTCP并不是完全通过免疫调理和GAL-3结合起作用 ,而是通过抑制增生对肿瘤小鼠爆发影响 。

     

    Comparative studies on the anti-tumor activities of high temperature- and pH-modified citrus pectins 

    Miao Hao, Xiaowen Yuan, Hairong Cheng, Huiting Xue, Tao Zhang, Yifa Zhou and Guihua Tai. 

    Food & Function, 2013, 4, 960–971 

    Abstract

    High temperature and pH modification could produce functional pectins. In this study, high temperaturemodified (HTCP) and pH-modified (MCP) citrus pectins were prepared for studying their anti-tumor activities in eight cancer cell lines and a mouse Sarcoma-180 (S-180) tumor model. HTCP inhibited the proliferation of these cancer cells and induced a caspase-3-dependent cell apoptosis and cell cycle arrest at G2/M phase. It also inhibited the growth of S-180 tumor to 49% of the control at the dose of 200 mg kg-1 –d 1 and extended the survival time of the tumor-bearing mice. MCP had no antiproliferative effects on these cancer cells and no anti-tumor effect in the mouse model. The anti-tumor activity of HTCP in the mouse tumor model was not correlated with immunomodulation and galectin-3 inhibition, but correlated well with proliferation inhibition. HTCP might be exploited as a functional food for cancer prevention and/or treatment.

     

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