918搏天堂

接待会见918搏天堂官方网站!

Literature

Contact us

Zhejiang Gold Kropn Bio-technology Co.,Ltd.

Tal:0570-8788056

Fax:0570-8788381

E-mail:zjgykp@163.com

Address:No.2,Donggang 4 Road,Donggang Economic Development Zone,Quzhou City,Zhejiang Province

  • The effects of low-esterified pectin on lead-induced thyroid injury in rats
  • date: 2019/3/29 visits:2189 
  •  

    The effects of low-esterified pectin on lead-induced thyroid injury in rats

    Environmental Toxicology and Pharmacology

    Volume 17, Issue 2, June 2004, Pages 67–71,http://dx.doi.org/10.1016/j.etap.2004.03.001

    Maxim Khotimchenkoa, Irina Sergushchenkoa, Yuri Khotimchenkob

    1  Pharmacology Department, Faculty of Pharmacy, Vladivostok State Medical University, Vladivostok, Russia

    2 Laboratory of Pharmacology, Institute of Marine Biology, Far East Branch of Russian Academy of Sciences, Vladivostok 690041, Russia

    Abstract

    The main purpose of the study was to evaluate the effects of low-esterified pectin on lead-induced thyroid injury in rats. Animals were fed 100 mg/kg of lead acetate through gavage for 3 weeks. After that, solution containing 50 mg/kg of low-esterified pectin was administered through gavage for 2 weeks. At the end of experiment, the endpoints related to circulating thyroid hormone (serum thyroxine and triiodothyronine), thyroid gland histomorphology (thyroid follicle cross sectional area, epithelial height, follicle roundness or aspect ratio, and colloid/epithelial ratio), and thyroid gland weight were assessed. Administration of lead resulted in reduced blood hormone levels, decreased thyroid gland weight, and impaired alterations in histomorphology. At the end of experiment, thyroid gland weight and blood hormone level were increased because of additional administration of low-esterified pectin. Also, signs of improved thyroid histomorphology were registered. The results obtained indicate the beneficial effects of low-esterified pectin on lead-induced thyroid injury.

  • previous:Equilibrium studies of sorptio
    next:Lead Absorption and Excretion
  • back
 

    Contact

  • Address:No.2 Donggang 4 Road ,Quzhou ,Zhejiang, China
  • Tel:86-570-8788056
  • Online:400-7118-600
  • E-mail:zjgykp@163.com

Coptyright © 2018 zjgykp.com All Rights Reserved. 浙ICP备19048970号-1
网站地图
友情链接:918博天堂下载  美狮贵宾会  金年会  腾博会官网  凯发K8旗舰厅  ng28南宫  AG旗舰厅官网  w88优德官网  南宫28  龙8唯一官网  凯发k8登录  利来国际ag  w88优德官网  来利国际w66  J9官网